![]() To mimic the function of these protein-based ion channels, artificial ionophores are being developed. The naturally occurring ion channels selectively transport a particular type of metal ions across the cellular membrane. Dysfunctional ion transport activity may cause Alzheimer's disease, Parkinson's disease, cystic fibrosis, vision disorders etc. The transport of ions across the semi-permeable cell membrane is a fundamental biological process that play key roles in signal transduction, nerve impulse, muscle contraction, hormonal regulation, and apoptosis 1, 2. This study may serve as a design principle to generate selective DNA-based artificial transporters for therapeutic applications. ![]() Moreover, the ionophore transports K +-ions across CHO and K-562 cell membranes. The preferential K +-ion transport is presumably due to conformational changes of the ionophore in response to different ions. Fluorescence assays, electrophysiology measurements and molecular dynamics simulations reveal that MG/ h-TELO preferentially transports K +-ions in a stimuli-responsive manner. MG stabilizes h-TELO by non-covalent interactions and, along with the lipophilic side chain, promotes the insertion of h-TELO within the hydrophobic lipid membrane. We herein delineate the construction of an artificial ionophore using a telomeric DNA G-quadruplex ( h-TELO) and a lipophilic guanosine ( MG). However, the development of stable and selective artificial ion transporters remains a formidable task. ![]() DNA-based systems have emerged as promising artificial ion transporters. The selective transport of ions across cell membranes, controlled by membrane proteins, is critical for a living organism. ![]()
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