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Or, you can capture the MODx_STATUSy wires, wait a while, transfer them into the shift register and shift them out at a later time, delay still longer after that is done, and only capture the MODx_STATUSy wires when nothing else is going on. ![]() So you can change the data latch even when you are actively shifting out a prior value. This is because the data latch isn't the shift register. The above capture can take place at any time during the serial-shifting process for an earlier capture. (You cannot capture some of them at different times from others.) Obviously, that means all 16 MODx_STATUSy wires are captured, simultaneously. Since both parts are tied to this control line, the rising edge affects both of them at the same time. A rising edge here will take a snapshot of the 16 MODx_STATUSy wires (pins 1-7 and 15) and capture it into the data latch. The way it's arranged, pin 12 ( RCK on the schematic) of both parts are wired in parallel to the control line named BP_STRB1. And that's a nice-to-have in a part like this. You can latch the parallel input independently from what's actively going on with the shift register. ![]() ![]() To mimic the function of these protein-based ion channels, artificial ionophores are being developed. The naturally occurring ion channels selectively transport a particular type of metal ions across the cellular membrane. Dysfunctional ion transport activity may cause Alzheimer's disease, Parkinson's disease, cystic fibrosis, vision disorders etc. The transport of ions across the semi-permeable cell membrane is a fundamental biological process that play key roles in signal transduction, nerve impulse, muscle contraction, hormonal regulation, and apoptosis 1, 2. This study may serve as a design principle to generate selective DNA-based artificial transporters for therapeutic applications. ![]() Moreover, the ionophore transports K +-ions across CHO and K-562 cell membranes. The preferential K +-ion transport is presumably due to conformational changes of the ionophore in response to different ions. Fluorescence assays, electrophysiology measurements and molecular dynamics simulations reveal that MG/ h-TELO preferentially transports K +-ions in a stimuli-responsive manner. MG stabilizes h-TELO by non-covalent interactions and, along with the lipophilic side chain, promotes the insertion of h-TELO within the hydrophobic lipid membrane. We herein delineate the construction of an artificial ionophore using a telomeric DNA G-quadruplex ( h-TELO) and a lipophilic guanosine ( MG). However, the development of stable and selective artificial ion transporters remains a formidable task. ![]() DNA-based systems have emerged as promising artificial ion transporters. 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